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Collaboration Arrangement (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 31 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Mar. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Collaboration revenue $ 1,212 $ 1,340 $ 3,813 $ 3,621    
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Collaboration revenue 1,200 $ 1,300 3,800 $ 3,600    
Deferred revenue 8,500   8,500   $ 8,500  
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Fixed consideration            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Performance obligation at inception of arrangement           $ 20,000
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Fixed consideration | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-04-01            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Timing of consideration to be received           2 years
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Achievement of regulatory milestones | Variable consideration            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Amount that can be earned upon achievement of milestone 66,000   66,000   66,000  
Regulatory milestone 3,000   3,000   3,000  
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Achievement of net sales milestones | Variable consideration            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Amount that can be earned upon achievement of net sales milestone $ 42,500   $ 42,500   42,500  
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Achievement of net sales milestones | Variable consideration | Fintepla            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Collaboration revenue         $ 0