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Collaboration Arrangement (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Mar. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Collaboration revenue $ 1,335 $ 1,249  
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Collaboration revenue 1,300 $ 1,200  
Deferred revenue 11,000    
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Fixed consideration      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Performance obligation at inception of arrangement     $ 20,000
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Fixed consideration | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-04-01      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Timing of consideration to be received     2 years
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Achievement of regulatory milestones | Variable consideration      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Amount that can be earned upon achievement of milestone 66,000    
Nippon Shinyaku Co., Ltd. (Shinyaku) | Collaborative arrangement | Achievement of net sales milestones | Variable consideration      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Amount that can be earned upon achievement of net sales milestone $ 42,500