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Stock-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2021
Share-based Payment Arrangement [Abstract]  
Summary of stock option activity The following is a summary of stock option activity for the three months ended March 31, 2021 (in thousands, except per share data):
Shares
Weighted-
Average
Exercise
Price per Share
Outstanding at December 31, 20205,311 $29.12 
Granted
946 18.96 
Exercised
(1)10.33 
Canceled
(75)33.73 
Outstanding at March 31, 20216,181 $27.51 
Schedule of restricted stock unit activity The following is a summary of our stock award activity for the three months ended March 31, 2021 (in thousands, except per share data):
RSUs
PSUs
Total
December 31, 2020393 — 393 
Granted(1)
450 482 932 
Vested
(119)— (119)
Canceled
(6)(3)(9)
Outstanding at March 31, 2021718 479 1,197 
(1) Weighted-average grant date fair value
$18.76 $19.60 $19.20 
Stock-based compensation expense
The following table summarizes the components of total stock-based compensation expense included in our condensed consolidated statements of operations:
Three Months Ended March 31,
(In thousands)20212020
Research and development$3,299 $2,729 
Selling, general and administrative4,799 3,665 
Total$8,098 $6,394 
The following table summarizes stock-based compensation expense by award type included in our condensed consolidated statements of operations:
Three Months Ended March 31,
(In thousands)20212020
Time-based stock options and restricted stock units$7,475 $6,242 
Performance-based stock units427 — 
Employee stock purchase plan (ESPP)196 152 
Total$8,098 $6,394