Cover Page - shares	3 Months Ended
	Mar. 31, 2021	Apr. 30, 2021
Cover [Abstract]
Document type	10-Q
Document quarterly report	true
Document period end date	Mar. 31, 2021
Document transition report	false
Entity file number	001-34962
Entity registrant name	ZOGENIX, INC.
Entity incorporation, state or country code	DE
Entity tax identification number	20-5300780
Entity address, address line one	5959 Horton Street
Entity address, address line two	Suite 500
Entity address, city or town	Emeryville
Entity address, state or province	CA
Entity address, postal zip code	94608
City area code	510
Local phone number	550-8300
Title of 12(b) security	Common Stock, par value $0.001 per share
Trading symbol	ZGNX
Security exchange name	NASDAQ
Entity current reporting status	Yes
Entity interactive data current	Yes
Entity filer category	Large Accelerated Filer
Entity small business	false
Entity emerging growth company	false
Entity shell company	false
Entity common stock, shares outstanding		55,812,590
Entity central index key	0001375151
Amendment flag	false
Document fiscal year focus	2021
Document fiscal period focus	Q1
Current fiscal year end date	--12-31