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Common Stock and Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2019
Share-based Payment Arrangement [Abstract]  
Summary of Stock Option Activity
The following is a summary of stock option activity for the nine months ended September 30, 2019 (in thousands, except per share data):
Shares
Weighted-
Average
Exercise
Price per Share
Outstanding at December 31, 20183,744  $20.69  
Granted
994  49.94  
Exercised
(544) 14.82  
Canceled
(81) 34.46  
Outstanding at September 30, 20194,113  $28.26  
Schedule of Restricted Stock Unit Activity
The following is a summary of restricted stock unit activity for the nine months ended September 30, 2019 (in thousands, except per share data):
Shares
Weighted- Average Fair Value per Share at Grant Date
Outstanding at December 31, 2018289  $25.56  
Granted
169  52.56  
Vested
(37) 43.10  
Canceled
(42) 32.20  
Outstanding at September 30, 2019379  $35.13  
Stock-Based Compensation Expense
The following table summarizes the components of total stock-based compensation expense included in the condensed consolidated statements of operations (in thousands):
Three Months Ended September 30,Nine Months Ended September 30,
2019201820192018
Research and development$2,012  $3,275  $5,521  $5,018  
Selling, general and administrative3,423  3,706  9,495  6,934  
Compensation expense related to acquired IPR&D4,927  —  4,927  —  
Total$10,362  $6,981  $19,943  $11,952