Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenue:
Total revenue	$ 0	$ 9,821	$ 28,850
Operating expenses (income):
Cost of contract manufacturing	0	10,729	22,173
Royalty expense	0	0	295
Research and development	100,925	67,449	41,840
Selling, general and administrative	38,950	25,885	26,996
Loss on contract termination	0	478	0
Change in fair value of contingent consideration	1,300	24,100	1,800
Asset impairment charges	0	1,116	8,431
Total operating expenses	141,175	129,757	101,535
Loss from operations	(141,175)	(119,936)	(72,685)
Other income (expense):
Interest income	7,170	1,090	443
Interest expense	(6)	(2,644)	(2,825)
Loss on extinguishment of debt	0	(4,876)	0
Change in fair value of common stock warrant liabilities	169	297	5,387
Other income (expense)	10,126	47	46
Total other income (expense)	17,459	(6,086)	3,051
Loss from continuing operations before income taxes	(123,716)	(126,022)	(69,634)
Income tax benefit	0	0	948
Loss from continuing operations	(123,716)	(126,022)	(68,686)
(Loss) income from discontinued operations	(198)	(795)	(1,021)
Net (loss) income	$ (123,914)	$ (126,817)	$ (69,707)
Net loss per share, basic and diluted:
Continuing operations (in usd per share)	$ (3.27)	$ (4.62)	$ (2.77)
Discontinued operations (in usd per share)	0	(0.03)	(0.04)
Net loss per share, basic and diluted (in dollars per share)	$ (3.27)	$ (4.65)	$ (2.81)
Weighted average shares outstanding, basic and diluted [Abstract]
Weighted average common shares outstanding, basic and diluted (shares)	37,884	27,301	24,785
Contract manufacturing revenue
Revenue:
Total revenue	$ 0	$ 9,821	$ 28,525
Service and other product revenue
Revenue:
Total revenue	$ 0	$ 0	$ 325