Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenue:
Contract manufacturing revenue	$ 0	$ 0	$ 0	$ 9,821
Costs and expenses:
Cost of contract manufacturing	0	0	0	10,729
Research and development	27,608	21,178	77,329	49,369
Selling, general and administrative	11,016	6,073	27,663	18,129
Loss on contract termination	0	478	0	478
Asset impairment charges	0	196	0	1,116
Change in fair value of contingent consideration	5,700	10,500	3,200	11,600
Total costs and expenses	44,324	38,425	108,192	91,421
Loss from operations	(44,324)	(38,425)	(108,192)	(81,600)
Other income (expense):
Interest income	2,133	121	3,995	332
Interest expense	0	(702)	(6)	(2,065)
Loss on extinguishment of debt	0	(3,378)	0	(3,378)
Change in fair value of common stock warrant liabilities	(64)	(380)	(95)	360
Other (expense) income, net	(9)	62	3,015	71
Total other income (expense)	2,060	(4,277)	6,909	(4,680)
Loss from continuing operations before income taxes	(42,264)	(42,702)	(101,283)	(86,280)
Income tax benefit	0	42	0	41
Net loss from continuing operations	(42,264)	(42,660)	(101,283)	(86,239)
Loss from discontinued operations, net of taxes	0	(134)	(198)	(870)
Net loss	$ (42,264)	$ (42,794)	$ (101,481)	$ (87,109)
Net loss per share, basic and diluted:
Continuing operations (in dollars per share)	$ (1.08)	$ (1.68)	$ (2.78)	$ (3.45)
Discontinued operations (in dollars per share)	0	0	0	(0.03)
Total (in dollars per share)	$ (1.08)	$ (1.68)	$ (2.78)	$ (3.48)
Weighted average common shares used in the calculation of basic and diluted net loss per common share (shares)	39,242	25,431	36,485	25,024