Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenue:
Contract manufacturing revenue	$ 0	$ 7,125	$ 0	$ 9,821
Costs and expenses:
Cost of contract manufacturing	0	8,242	0	10,729
Research and development	26,741	14,850	49,721	28,191
Selling, general and administrative	8,577	5,502	16,647	12,056
Asset impairment charges	0	107	0	920
Change in fair value of contingent consideration	(2,500)	500	(2,500)	1,100
Total costs and expenses	32,818	29,201	63,868	52,996
Loss from operations	(32,818)	(22,076)	(63,868)	(43,175)
Other income (expense):
Interest income	1,029	117	1,862	211
Interest expense	0	(692)	(6)	(1,363)
Change in fair value of common stock warrant liabilities	(48)	153	(31)	740
Other income, net	2,998	29	3,024	9
Total other income (expense)	3,979	(393)	4,849	(403)
Loss from continuing operations before income taxes	(28,839)	(22,469)	(59,019)	(43,578)
Income tax benefit (expense)	0	16	0	(1)
Net loss from continuing operations	(28,839)	(22,453)	(59,019)	(43,579)
Loss from discontinued operations, net of taxes	(198)	(555)	(198)	(736)
Net loss	$ (29,037)	$ (23,008)	$ (59,217)	$ (44,315)
Net loss per share, basic and diluted:
Continuing operations (in dollars per share)	$ (0.82)	$ (0.90)	$ (1.68)	$ (1.76)
Discontinued operations (in dollars per share)	(0.01)	(0.03)	(0.01)	(0.03)
Total (in dollars per share)	$ (0.83)	$ (0.93)	$ (1.69)	$ (1.79)
Weighted average shares outstanding, basic and diluted (shares)	35,355	24,822	35,099	24,817
Statements of Comprehensive Income (Loss)
Comprehensive loss	$ (29,037)	$ (23,008)	$ (59,217)	$ (44,315)