Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenue:
Contract manufacturing revenue	$ 9,821	$ 28,525	$ 24,369
Service and other product revenue	0	325	2,813
Total revenue	9,821	28,850	27,182
Operating expenses (income):
Cost of contract manufacturing	10,729	22,173	22,356
Royalty expense	0	295	345
Research and development	67,449	41,840	27,860
Selling, general and administrative	25,885	26,996	26,347
Loss on contract termination	478	0	0
Change in fair value of contingent consideration	24,100	1,800	(2,000)
Asset impairment charges	1,116	8,431	0
Total operating expenses	129,757	101,535	74,908
Loss from operations	(119,936)	(72,685)	(47,726)
Other income (expense):
Interest income	1,090	443	101
Interest expense	(2,644)	(2,825)	(3,060)
Loss on sale of marketable securities	0	0	(5,746)
Loss on extinguishment of debt	(4,876)	0	0
Change in fair value of common stock warrant liabilities	297	5,387	(1,103)
Other income (expense)	47	46	(71)
Total other income (expense)	(6,086)	3,051	(9,879)
Loss from continuing operations before income taxes	(126,022)	(69,634)	(57,605)
Income tax benefit	0	948	15,901
Loss from continuing operations	(126,022)	(68,686)	(41,704)
(Loss) income from discontinued operations	(795)	(1,021)	67,848
Net (loss) income	$ (126,817)	$ (69,707)	$ 26,144
Net (loss) income per share, basic:
Net (loss) income per share, basic - continuing operations (in dollars per share)	$ (4.62)	$ (2.77)	$ (1.94)
Net (loss) income per share, basic - discontinued operations (in dollars per share)	(0.03)	(0.04)	3.16
Net (loss) income per share, basic (in dollars per share)	(4.65)	(2.81)	1.22
Net (loss) income per share, diluted:
Net (loss) income per share, diluted - continuing operations (in dollars per share)	(4.62)	(2.77)	(1.94)
Net (loss) income per share, diluted - discontinued operations (in dollars per share)	(0.03)	(0.04)	3.16
Net (loss) income per share, diluted (in dollars per share)	$ (4.65)	$ (2.81)	$ 1.22
Weighted average shares outstanding, basic and diluted [Abstract]
Weighted average shares outstanding, basic (in shares)	27,301	24,785	21,449
Weighted average shares outstanding, diluted (in shares)	27,301	24,785	21,449