Summary of Significant Accounting Policies - Property and Equipment, Net Narrative (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2017	Dec. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Depreciation			$ 425,000	$ 1,402,000	$ 1,621,000
Goodwill impairment			$ 0	0	0
Impairment charges					0
Computer equipment and software [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, useful life			3 years
Furniture and fixtures [Member] | Minimum [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, useful life			3 years
Furniture and fixtures [Member] | Maximum [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, useful life			7 years
Long Lived Assets, Production [Member] | Sumavel DosePro [Member]
Property, Plant and Equipment [Line Items]
Impairment charges	$ 800,000	$ 6,400,000
IPR&D [Member]
Property, Plant and Equipment [Line Items]
Impairment of IPR&D			$ 0	$ 0	$ 0