Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenue:
Contract manufacturing revenue	$ 0	$ 6,345	$ 9,821	$ 17,537
Service and other product revenue	0	225	0	327
Total revenue	0	6,570	9,821	17,864
Costs and expenses:
Cost of contract manufacturing	0	6,469	10,729	16,480
Research and development	21,178	10,076	49,369	28,447
Selling, general and administrative	6,073	6,538	18,129	19,506
Loss on contract termination	478	0	478	0
Asset impairment charges	196	0	1,116	0
Change in fair value of contingent consideration	10,500	200	11,600	2,800
Total costs and expenses	38,425	23,283	91,421	67,233
Loss from operations	(38,425)	(16,713)	(81,600)	(49,369)
Other income (expense):
Interest expense, net	(581)	(567)	(1,733)	(1,788)
Loss on extinguishment of debt	(3,378)	0	(3,378)	0
Change in fair value of common stock warrant liabilities	(380)	(356)	360	5,148
Other income	62	25	71	2
Total other (expense) income	(4,277)	(898)	(4,680)	3,362
Loss from continuing operations before income taxes	(42,702)	(17,611)	(86,280)	(46,007)
Income tax benefit	42	993	41	922
Net loss from continuing operations	(42,660)	(16,618)	(86,239)	(45,085)
Net loss from discontinued operations	(134)	(379)	(870)	(1,130)
Net loss	$ (42,794)	$ (16,997)	$ (87,109)	$ (46,215)
Net loss per share, basic and diluted:
Continuing operations (in dollars per share)	$ (1.68)	$ (0.67)	$ (3.45)	$ (1.82)
Discontinued operations (in dollars per share)	0.00	(0.02)	(0.03)	(0.05)
Total (in dollars per share)	$ (1.68)	$ (0.69)	$ (3.48)	$ (1.87)
Weighted average shares outstanding, basic and diluted (shares)	25,431	24,791	25,024	24,780
Statements of Comprehensive Income (Loss)
Comprehensive loss	$ (42,794)	$ (16,997)	$ (87,109)	$ (46,215)