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Stock-Based Compensation - Assumptions used in Black-Scholes Option-Pricing Model (Detail) - Stock Options
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Risk free interest rate, minimum 1.90% 1.10% 1.90% 1.10%
Risk free interest rate, maximum 2.10% 1.30% 2.30% 1.40%
Expected volatility, minimum 75.10% 77.00% 75.10% 77.00%
Expected volatility, maximum 75.50% 78.10% 76.60% 78.10%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Minimum        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expected term 6 years 1 month 5 years 1 month 6 days 5 years 1 month 6 days 5 years 1 month 6 days
Maximum        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expected term 6 years 1 month 6 years 1 month 6 years 1 month 6 years 1 month