Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2017

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Assumptions used in the Black-Scholes Option-Pricing Model

	Three Months Ended September 30,		Nine Months Ended September 30,
	2017	2016	2017	2016
Risk free interest rate	1.9% to 2.1%	1.1% to 1.3%	1.9% to 2.3%	1.1% to 1.4%
Expected term	6.1 years	5.1 to 6.1 years	5.1 to 6.1 years	5.1 to 6.1 years
Expected volatility	75.1% to 75.5%	77.0% to 78.1%	75.1% to 76.6%	77.0% to 78.1%
Expected dividend yield	—%	—%	—%	—%

Stock-Based Compensation Expense

The following table summarizes the components of total stock-based compensation expense included in the condensed consolidated statements of operations (in thousands):

	Three Months Ended September 30,				Nine Months Ended September 30,
	2017		2016		2017		2016
Cost of contract manufacturing	$	—	$	98	$	71	$	294
Research and development	294		532		1,313		1,449
Selling, general and administrative	968		1,311		2,682		3,460
Total	$	1,262	$	1,941	$	4,066	$	5,203