Income Taxes - Schedule of Deferred Tax Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
State taxes, net of federal benefit	$ (65)	$ (691)	$ 1,499
Net operating losses	90,543	72,402
Capitalized research and development	4,504	5,768
Accrued expenses	1,240	1,266
Research and development credits	4,596	4,451
Accrued product returns	34	324
Inventory reserve and UNICAP	175	1,063
Deferred Tax Assets, Goodwill and Intangible Assets	1,680	1,998
Amortization	1,533	0
Deferred revenue	475	3,494
Other, net	7,542	6,432
Total deferred tax assets	112,322	97,198
Less valuation allowance	(112,322)	(96,298)
Net deferred tax assets	0	900
Depreciation	0	(900)
IPR&D	(17,425)	(18,450)
Total deferred tax liabilities	(17,425)	(19,350)
Net deferred tax liability	(17,425)	(18,450)
Change in valuation allowance	16,024	(14,042)	(12,968)
Valuation allowance adjustment for continuing operations	0	15,498	0
Permanent interest disallowed	(1,832)	375	(8,608)
Foreign rate change - Impact on Deferred Taxes	521	(1,993)	0
Other permanent differences	1,307	114	1,226
Research and development tax credits	(145)	(1,060)	(1,387)
State tax rate benefit	578	2,181	(503)
Foreign rate differential	6,122	2,550	0
Credits and other	$ 217	$ 753	$ (109)