Collaboration, License and Purchase Agreements - Narrative (Details) - USD ($)		1 Months Ended			12 Months Ended
	Oct. 24, 2014	Oct. 31, 2016	Jun. 30, 2015	Dec. 31, 2014	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Service and other product revenue					$ 325,000	$ 2,813,000	$ 3,715,000
Research and development					41,840,000	27,860,000	11,893,000
Payments to Acquire in Process Research and Development		$ 1,500,000
Valeant Pharmaceuticals North America LLC Co-Promotions Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Service and other product revenue					0	347,000	3,357,000
Durect Development and License Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development					$ 345,000	$ 4,572,000	4,251,000
Minimum future milestone payments							$ 103,000,000
Royalty agreement term							15 years
Aradigm Corporation Asset Purchase Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty rate					3.00%
Expected amortization expense, 2017					$ 286,000
Expected amortization expense, 2018					286,000
Expected amortization expense, 2019					286,000
Expected amortization expense, 2020					$ 286,000
Brabant Pharma Limited [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate amount of contingent liabilities	$ 95,000,000
Regulatory Milestones [Member] | Brabant Pharma Limited [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate amount of contingent liabilities	50,000,000
Sales Milestones [Member] | Brabant Pharma Limited [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate amount of contingent liabilities	$ 45,000,000
Migranal [Member] | Sales Revenue, Services, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contract termination payment			$ 500,000
Minimum [Member] | Endo Ventures Supply Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Term of agreement				8 years
Minimum [Member] | Durect Development and License Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Annual external development expense obligation							$ 1,000,000