Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenue:
Contract manufacturing revenue	$ 28,525	$ 24,369	$ 15,392
Net product revenue	0	0	9,840
Service and other product revenue	325	2,813	3,715
Total revenue	28,850	27,182	28,947
Operating expenses (income):
Cost of contract manufacturing	22,173	22,356	14,342
Cost of goods sold	0	0	5,263
Royalty expense	295	345	591
Research and development	41,840	27,860	11,893
Selling, general and administrative	26,996	26,347	34,639
Change in fair value of contingent consideration	1,800	(2,000)	0
Impairment charges	8,431	0	838
Net gain on sale of business	0	0	(79,980)
Total operating expenses (income)	101,535	74,908	(12,414)
(Loss) income from operations	(72,685)	(47,726)	41,361
Other income (expense):
Interest Income, Domestic Deposits	443	101	20
Interest expense	(2,825)	(3,060)	(3,090)
Loss on sale of short-term investments	0	(5,746)	0
Loss on extinguishment of debt	0	0	(1,254)
Change in fair value of common stock warrant liabilities	5,387	(1,103)	25,332
Change in fair value of embedded derivatives	0	0	(14)
Other income (expense)	46	(71)	(784)
Total other income (expense)	3,051	(9,879)	20,210
(Loss) income from continuing operations before income taxes	(69,634)	(57,605)	61,571
Income tax benefit (expense)	948	15,901	(84)
(Loss) income from continuing operations	(68,686)	(41,704)	61,487
Net loss (income) from discontinued operations	(1,021)	67,848	(52,900)
Net (loss) income	$ (69,707)	$ 26,144	$ 8,587
Net (loss) income per share, basic:
Basic net income (loss) per share (in dollars per share)	$ (2.77)	$ (1.94)	$ 3.45
Basic net income (loss) per share (in dollars per share)	(0.04)	3.16	(2.97)
Total (in dollars per share)	(2.81)	1.22	0.48
Net (loss) income per share, diluted:
Income (Loss) from Continuing Operations, Per Diluted Share	(2.77)	(1.94)	3.44
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share	(0.04)	3.16	(2.96)
Total (in dollars per share)	$ (2.81)	$ 1.22	$ 0.48
Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]
Weighted average shares outstanding, basic (in shares)	24,785	21,449	17,825
Weighted average common shares outstanding, diluted (in shares)			17,855