Subsequent events (Details) - USD ($) $ in Thousands	1 Months Ended
Oct. 31, 2016	Sep. 30, 2016
Subsequent Event [Line Items]
Manufacturing services agreement with Patheon UK Limited		$ 4,600
Subsequent Event
Subsequent Event [Line Items]
Payments to acquire global rights to a preclinical development program	$ 1,500

The cash outflows from the purchase of net carrying value allocated to in-process research and development costs and materials acquired in a business combination.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 13
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3213-108585

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Investing Activities
-URI http://asc.fasb.org/extlink&oid=6516133

Name:	us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration