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Discontinued operations - Narrative (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2016
Sep. 30, 2015
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]      
Stock-based compensation   $ 5,203,000 $ 5,981,000
Zohydro ER | Discontinued Operations      
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]      
Stock-based compensation $ 0 0 905,000
Amortization $ 0 $ 0 $ 166,000