Common Stock Warrant Liability - Additional Informational (Detail) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended		3 Months Ended
	Jul. 27, 2012	Jul. 31, 2012	Jul. 31, 2011	Mar. 31, 2016	Dec. 31, 2015
Schedule Of Common Stock [Line Items]
Shares of common stock exercisable through warrants				1,901,918
Warrants exercise price per share	$ 20.00
Term of common stock warrant exercisable (years)	5 years		10 years
Fair value of warrant liabilities				$ 1,603	$ 6,069
Warrant exercisable to Healthcare Royalty, shares			28,125
Warrant exercisable to Healthcare Royalty, price per share (usd per share)			$ 72.00
Healthcare Royalty
Schedule Of Common Stock [Line Items]
Fair value of warrant liabilities				$ 66	$ 127
IPO
Schedule Of Common Stock [Line Items]
Number of shares issued in public offering		1,973,025