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Discontinued operations - Narrative (Details) - USD ($)
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]    
Stock-based compensation $ 1,488,000 $ 1,871,000
Zohydro ER | Discontinued Operations    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]    
Stock-based compensation 0 522,000
Amortization $ 0 $ 124,000