Income Taxes - Schedule of Deferred Tax Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
Net operating losses	$ 72,402	$ 82,054
Capitalized research and development	5,768	7,176
Accrued expenses	1,266	2,030
Research and development credits	4,451	3,395
Accrued product returns	324	1,772
Inventory reserve and UNICAP	1,063	2,956
Amortization	1,998	2,556
Deferred revenue	3,494	4,446
Other, net	6,432	5,128
Total deferred tax assets	97,198	111,513
Less valuation allowance	(96,298)	(110,338)
Net deferred tax assets	900	1,175
Depreciation	(900)	(1,175)
IPR&D	(18,450)	(20,500)
Total deferred tax liabilities	(19,350)	(21,675)
Net deferred tax liability	$ (18,450)	$ (20,500)