Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue:
Contract manufacturing revenue	$ 24,369	$ 15,392	$ 0
Net product revenue	0	9,840	31,699
Service and other product revenue	2,813	3,715	1,313
Total revenue	27,182	28,947	33,012
Operating expenses (income):
Cost of contract manufacturing	22,356	14,342	0
Cost of goods sold	0	5,263	21,241
Royalty expense	345	591	1,242
Research and development	27,860	11,893	8,372
Selling, general and administrative	26,347	34,639	46,218
Change in fair value of contingent consideration	(2,000)	0	0
Restructuring	0	0	876
Impairment of long-lived assets	0	838	0
Net gain on sale of business	0	(79,980)	0
Total operating expenses (income)	74,908	(12,414)	77,949
Loss (income) from operations	(47,726)	41,361	(44,937)
Other income (expense):
Interest expense, net	(2,959)	(3,070)	(6,592)
Loss on sale of short-term investments	(5,746)	0	0
Loss on extinguishment of debt	0	(1,254)	0
Change in fair value of warrant liabilities	(1,103)	25,332	(21,927)
Change in fair value of embedded derivatives	0	(14)	759
Other income (expense)	(71)	(784)	96
Total other income (expense)	(9,879)	20,210	(27,664)
Net income (loss) from continuing operations before income taxes	(57,605)	61,571	(72,601)
Benefit (provision) for income taxes	15,901	(84)	0
Net income (loss) from continuing operations	(41,704)	61,487	(72,601)
Net income (loss) from discontinued operations	67,848	(52,900)	(8,255)
Net income (loss)	$ 26,144	$ 8,587	$ (80,856)
Basic net income (loss) per share:
Basic net income (loss) per share (in dollars per share)	$ (1.94)	$ 3.45	$ (5.35)
Basic net income (loss) per share (in dollars per share)	3.16	(2.97)	(0.61)
Total (in dollars per share)	1.22	0.48	(5.96)
Diluted net income (loss) per share:
Income (Loss) from Continuing Operations, Per Diluted Share	(1.94)	3.44	(5.35)
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share	3.16	(2.96)	(0.61)
Total (in dollars per share)	$ 1.22	$ 0.48	$ (5.96)
Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]
Weighted average shares outstanding, basic (in shares)	21,449	17,825	13,571
Weighted average common shares outstanding, diluted (in shares)	21,449	17,855	13,571