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Consolidated Statements of Operations and Comprehensive Loss (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Revenue:    
Net product revenue $ 0us-gaap_SalesRevenueGoodsNet $ 6,485us-gaap_SalesRevenueGoodsNet
Contract revenue 4,181us-gaap_ContractsRevenue 0us-gaap_ContractsRevenue
Service and other product revenue 433us-gaap_SalesRevenueServicesGross 904us-gaap_SalesRevenueServicesGross
Total revenue 4,614us-gaap_Revenues 7,389us-gaap_Revenues
Operating expenses:    
Cost of sales 0us-gaap_CostOfGoodsAndServicesSold 3,333us-gaap_CostOfGoodsAndServicesSold
Cost of contract manufacturing 3,923us-gaap_ContractRevenueCost 0us-gaap_ContractRevenueCost
Royalty expense 72us-gaap_RoyaltyExpense 267us-gaap_RoyaltyExpense
Research and development 5,150us-gaap_ResearchAndDevelopmentExpense 2,541us-gaap_ResearchAndDevelopmentExpense
Selling, general and administrative 6,268us-gaap_SellingGeneralAndAdministrativeExpense 12,528us-gaap_SellingGeneralAndAdministrativeExpense
Change in fair value of contingent purchase consideration (1,000)us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1 0us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1
Total operating expenses 14,413us-gaap_OperatingExpenses 18,669us-gaap_OperatingExpenses
Loss from operations (9,799)us-gaap_OperatingIncomeLoss (11,280)us-gaap_OperatingIncomeLoss
Other income (expense):    
Interest income 5us-gaap_InvestmentIncomeInterest 6us-gaap_InvestmentIncomeInterest
Interest expense (648)us-gaap_InterestExpense (1,886)us-gaap_InterestExpense
Change in fair value of warrant liabilities 410us-gaap_FairValueOptionChangesInFairValueGainLoss1 8,269us-gaap_FairValueOptionChangesInFairValueGainLoss1
Change in fair value of embedded derivatives 0us-gaap_DerivativeGainLossOnDerivativeNet (14)us-gaap_DerivativeGainLossOnDerivativeNet
Other income (expense) (120)us-gaap_OtherNonoperatingIncomeExpense (47)us-gaap_OtherNonoperatingIncomeExpense
Total other income (expense) (353)us-gaap_NonoperatingIncomeExpense 6,328us-gaap_NonoperatingIncomeExpense
Net loss before income taxes (10,152)us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments (4,952)us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments
Provision for income taxes (13)us-gaap_IncomeTaxExpenseBenefit 0us-gaap_IncomeTaxExpenseBenefit
Net loss from continuing operations (10,165)us-gaap_IncomeLossFromContinuingOperations (4,952)us-gaap_IncomeLossFromContinuingOperations
Loss from discontinued operations, net of applicable tax (12,696)us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity (15,980)us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity
Net loss (22,861)us-gaap_NetIncomeLoss (20,932)us-gaap_NetIncomeLoss
Basic net loss per share:    
Continuing operations, usd per share $ (0.07)us-gaap_IncomeLossFromContinuingOperationsPerBasicShare $ (0.04)us-gaap_IncomeLossFromContinuingOperationsPerBasicShare
Discontinued operations, usd per share $ (0.08)us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare $ (0.11)us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare
Total, usd per share $ (0.15)us-gaap_EarningsPerShareBasic $ (0.15)us-gaap_EarningsPerShareBasic
Diluted net loss per share:    
Continuing operations, usd per share $ (0.07)us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare $ (0.09)us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare
Discontinued operations, usd per share $ (0.08)us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare $ (0.11)us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare
Net income (loss) per share, diluted, usd per share $ (0.15)us-gaap_EarningsPerShareDiluted $ (0.20)us-gaap_EarningsPerShareDiluted
Weighted average common shares outstanding, basic 153,362us-gaap_WeightedAverageNumberOfSharesOutstandingBasic 139,309us-gaap_WeightedAverageNumberOfSharesOutstandingBasic
Weighted average common shares outstanding, diluted 153,362us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding 145,323us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding
Comprehensive loss $ (22,861)us-gaap_ComprehensiveIncomeNetOfTax $ (20,932)us-gaap_ComprehensiveIncomeNetOfTax