Debt - Healthcare Royalty Financing Agreement Narrative (Details) (USD $)	0 Months Ended		12 Months Ended
	Jul. 27, 2012	Jul. 18, 2011	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Jul. 31, 2012
Debt Instrument [Line Items]
Long-term debt interest expense			$ 5,672,000	$ 6,708,000	$ 5,562,000
Common stock issued and sold to Healthcare Royalty, amount			139,000	101,000
Common stock issued and sold to Healthcare Royalty, shares			138,927,000	100,809,000
Common stock issued and sold to Healthcare Royalty, (usd per share)			$ 1.66
Warrant exercisable to Healthcare Royalty, shares		225,000
Warrant exercisable to Healthcare Royalty, (usd per share)		$ 9.00
Period For Warrant Term	5 years	10 years
Long-term Debt						25,000,000
Change in fair value of embedded derivatives			759,000	(147,000)	(240,000)
Embedded Derivative Liabilities [Member]
Debt Instrument [Line Items]
Fair value of embedded derivatives			233,000	992,000
Change in fair value			(759,000)	147,000
Healthcare Royalty Financing Agreement [Member]
Debt Instrument [Line Items]
Company closed royalty financing agreement		Jul. 18, 2011
Debt instrument, outstanding		30,000,000
Common stock issued and sold to Healthcare Royalty, amount		1,500,000
Common stock issued and sold to Healthcare Royalty, shares		388,601
Common stock issued and sold to Healthcare Royalty, (usd per share)		$ 3.86
Revenue interest rate		0.50%
Net product sales amount received		10,000,000
Number of fixed payments		3
Fixed payment for Jan 31, 2015		10,000,000
Fixed payment for Jan 31, 2016			10,000,000
Fixed payment for Jan 31, 2017			10,000,000
Fixed debt repayment dates		January 31, 2015, January 31, 2016 and January 31, 2017
Terminate payment base amount			75,000,000
Change in fair value					417,000
Aggregate net proceed from financing agreement		29,485,000
Financing discounts		476,000
Healthcare Royalty Financing Agreement [Member] | Embedded Derivative Liabilities [Member]
Debt Instrument [Line Items]
Financing discounts		605,000
Healthcare Royalty Financing Agreement [Member] | Common Stock Warrant Liabilities [Member]
Debt Instrument [Line Items]
Change in fair value			(307,000)	160,000
Financing discounts		790,000
Healthcare Royalty Financing Agreement [Member] | Scenario 1[Member]
Debt Instrument [Line Items]
Net product sales amount received		75,000,000
Terminate payment base amount			52,500,000
Borrowed internal rate of return			19.00%
Healthcare Royalty Financing Agreement [Member] | Scenario 1[Member] | Minimum [Member]
Debt Instrument [Line Items]
Revenue interest rate		5.00%
Healthcare Royalty Financing Agreement [Member] | Scenario 1[Member] | Maximum [Member]
Debt Instrument [Line Items]
Revenue interest rate		5.75%
Healthcare Royalty Financing Agreement [Member] | Scenario 2[Member]
Debt Instrument [Line Items]
Revenue interest rate		2.50%
Net product sales amount received		75,000,000
Terminate payment base amount			45,000,000
Borrowed internal rate of return			17.00%
Healthcare Royalty Financing Agreement [Member] | Scenario 3[Member]
Debt Instrument [Line Items]
Revenue interest rate		0.50%
Net product sales amount received		$ 150,000,000