Consolidated Statements of Operations and Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenue:
Net product revenue	$ 31,699	$ 35,826	$ 30,411
Contract revenue	0	8,462	7,165
Service and other revenue	1,313	38	0
Total revenue	33,012	44,326	37,576
Operating expenses:
Cost of sales	21,241	19,496	19,293
Royalty expense	1,242	1,353	1,205
Research and development	12,805	21,414	33,043
Selling, general and administrative	50,040	49,494	60,459
Restructuring	876	0	0
Total operating expenses	86,204	91,757	114,000
Loss from operations	(53,192)	(47,431)	(76,424)
Other income (expense):
Interest income	18	53	37
Interest expense	(6,610)	(10,313)	(7,644)
Change in fair value of warrant liabilities	(21,927)	11,811	445
Change in fair value of embedded derivatives	759	(147)	(240)
Other income (expense)	96	(1,354)	(86)
Total other income (expense)	(27,664)	50	(7,488)
Loss before income taxes	(80,856)	(47,381)	(83,912)
Provision for income tax benefit (expense)	0	(5)	9
Net loss	(80,856)	(47,386)	(83,903)
Net loss per share, basic and diluted	$ (0.74)	$ (0.59)	$ (1.96)
Weighted average shares outstanding, basic and diluted	108,568	80,558	42,712
Comprehensive loss	$ (80,856)	$ (47,386)	$ (83,903)