-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 e4V79FKHLyT5m7rhs++dvA==

<SEC-DOCUMENT>0001375151-09-000006.txt : 20091005
<SEC-HEADER>0001375151-09-000006.hdr.sgml : 20091005
<ACCEPTANCE-DATETIME>20091002190748
ACCESSION NUMBER:		0001375151-09-000006
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091005
DATE AS OF CHANGE:		20091002
EFFECTIVENESS DATE:		20091005

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ZOGENIX INC
		CENTRAL INDEX KEY:			0001375151
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				205300780
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-94611
		FILM NUMBER:		091103887

	BUSINESS ADDRESS:	
		STREET 1:		12671 HIGH BLUFF DRIVE
		STREET 2:		SUITE 200
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(858) 259-1165

	MAIL ADDRESS:	
		STREET 1:		12671 HIGH BLUFF DRIVE
		STREET 2:		SUITE 200
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001375151</cik>
        <entityName>ZOGENIX INC</entityName>
        <issuerAddress>
            <street1>12671 HIGH BLUFF DRIVE</street1>
            <street2>SUITE 200</street2>
            <city>SAN DIEGO</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>92130</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(858) 259-1165</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>SJ2 Therapeutics, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2006</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Roger</firstName>
                <middleName>L.</middleName>
                <lastName>Hawley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <middleName>J.</middleName>
                <lastName>Farr</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>W.</middleName>
                <lastName>Nassif</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Cynthia</firstName>
                <middleName>Y.</middleName>
                <lastName>Robinson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J.D.</firstName>
                <lastName>Haldeman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Cam</firstName>
                <middleName>L.</middleName>
                <lastName>Garner</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kurt</firstName>
                <middleName>C.</middleName>
                <lastName>Wheeler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Clarus Ventures, One Memorial Drive</street1>
                <street2>Suite 1230</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02142</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>C.</middleName>
                <lastName>Blair</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Domain Associates, L.L.C.</street1>
                <street2>One Palmer Square, Suite 515</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08542</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Louis</firstName>
                <middleName>C.</middleName>
                <lastName>Bock</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Scale Venture Partners</street1>
                <street2>950 Tower Lane, Suite 700</street2>
                <city>Foster City</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94404</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alex</firstName>
                <lastName>Zisson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Thomas, McNerney &amp; Partners</street1>
                <street2>60 South 6th Street, Suite 3620</street2>
                <city>Minneapolis</city>
                <stateOrCountry>MN</stateOrCountry>
                <zipCode>55402</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Erle</firstName>
                <middleName>T.</middleName>
                <lastName>Mast</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Zogenix, Inc., 12671 High Bluff Dr.</street1>
                <street2>Suite 200</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-09-22</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>60457956</totalOfferingAmount>
            <totalAmountSold>35957968</totalAmountSold>
            <totalRemaining>24499988</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>13</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ZOGENIX INC</issuerName>
                <signatureName>/s/ David W. Nassif</signatureName>
                <nameOfSigner>David W. Nassif</nameOfSigner>
                <signatureTitle>Executive VP, CFO &amp; Secretary</signatureTitle>
                <signatureDate>2009-10-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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