Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenue:
Net product revenue	$ 8,453	$ 8,835	$ 26,368	$ 24,986
Contract revenue	0	1,563	8,462	4,688
Total revenue	8,453	10,398	34,830	29,674
Operating expenses:
Cost of sales	4,249	5,482	13,478	14,333
Royalty expense	325	343	997	972
Research and development	3,660	10,134	16,005	27,540
Selling, general and administrative	10,857	14,701	37,574	42,642
Total operating expenses	19,091	30,660	68,054	85,487
Loss from operations	(10,638)	(20,262)	(33,224)	(55,813)
Other income (expense):
Interest income	11	2	40	21
Interest expense	(3,463)	(2,470)	(8,730)	(4,984)
Change in fair value of warrant liabilities	(3,569)	546	(3,611)	546
Change in fair value of embedded derivatives	(202)	137	166	137
Other income (expense)	(1,421)	16	(1,379)	(86)
Total other income (expense)	(8,644)	(1,769)	(13,514)	(4,366)
Net loss before income taxes	(19,282)	(22,031)	(46,738)	(60,179)
Provision for income taxes	0	(7)	(5)	(20)
Net loss	$ (19,282)	$ (22,038)	$ (46,743)	$ (60,199)
Net loss per share, basic and diluted	$ (0.21)	$ (0.59)	$ (0.63)	$ (1.71)
Weighted average shares outstanding, basic and diluted	90,370	37,320	73,790	35,127