Consolidated Statements Of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenue:
Net product revenue	$ 30,411	$ 19,069	$ 0
Contract revenue	7,165	4,373	0
Total revenue	37,576	23,442	0
Operating expenses:
Cost of sales	19,293	12,846	0
Royalty expense	1,205	843	0
Research and development	33,043	28,643	21,438
Selling, general and administrative	60,459	51,270	14,102
Total operating expenses	114,000	93,602	35,540
Loss from operations	(76,424)	(70,160)	(35,540)
Other income (expense):
Interest income	37	5	10
Interest expense	(7,644)	(10,013)	(9,188)
Change in fair value of warrant liability	445	6,725	(755)
Change in fair value of embedded derivatives	(240)	0	0
Other expense	(86)	(111)	(416)
Total other income (expense)	(7,488)	(3,394)	(10,349)
Loss before income taxes	(83,912)	(73,554)	(45,889)
Provision for income tax benefit (expense)	9	(10)	0
Net loss	$ (83,903)	$ (73,564)	$ (45,889)
Net loss per share, basic and diluted	$ (1.96)	$ (17.63)	$ (40.97)
Weighted average shares outstanding, basic and diluted	42,712	4,173	1,120