POWER OF ATTORNEY

	Know all by these presents, that the undersigned hereby constitutes and appoints each of Ann D. Rhoads
and Thomas Doyle, signing singly, with full power of substitution, as the undersigned's true and
lawful attorney-in-fact to:

(1)     prepare, execute in the undersigned's name and on the undersigned's behalf, and submit
	to the U.S. Securities and Exchange Commission (the "SEC") a Form ID, including amendments
	thereto, and any other documents necessary or appropriate to obtain codes and passwords
	enabling the undersigned to make electronic filings with the SEC of reports required by Section
	16(a) of the Securities Exchange Act of 1934 or any rule or regulation of the SEC;

(2)	execute for and on behalf of the undersigned, in the undersigned's capacity as an officer
	and/or director of Zogenix, Inc. (the "Company") and/or 10% holder of the Company's capital
	stock, Forms 3, 4, and 5 and any amendments thereto in accordance with Section 16(a) of the
	Securities Exchange Act of 1934 and the rules thereunder;

(3)     do and perform any and all acts for and on behalf of the undersigned which may be
	necessary or desirable to complete and execute any such Form 3, 4, or 5, complete and execute
	any amendment or amendments thereto, and timely file such form with the SEC and any stock
	exchange or similar authority; and

(4)     take any other action of any type whatsoever in connection with the foregoing which, in
	the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally
	required by, the undersigned, it being understood that the documents executed by such attorney-in-fact
	on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and
	shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's
	discretion.

	The undersigned hereby grants to each such attorney-in-fact full power and authority to do and
perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise
of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned
might or could do if personally present, with full power of substitution or revocation, hereby ratifying and
confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully
do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request
of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's
responsibilities to comply with Section 16 of the Securities Exchange Act of 1934.

	This Power of Attorney shall remain in full force and effect until the undersigned is no longer
required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and transactions in
securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered
to the foregoing attorneys-in-fact.

	IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as
of this 6th day of February, 2015.


Signature:       /s/ Renee P. Tannenbaum
Print Name:      Renee P. Tannenbaum