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Consolidated Statements of Operations and Comprehensive Loss (USD $)
In Thousands, except Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Income Statement [Abstract]      
Revenue $ 0us-gaap_Revenues $ 0us-gaap_Revenues $ 0us-gaap_Revenues
Operating expenses:      
Research and development 27,391us-gaap_ResearchAndDevelopmentExpense 9,561us-gaap_ResearchAndDevelopmentExpense 11,544us-gaap_ResearchAndDevelopmentExpense
General and administrative 8,141us-gaap_GeneralAndAdministrativeExpense 4,219us-gaap_GeneralAndAdministrativeExpense 2,247us-gaap_GeneralAndAdministrativeExpense
Total operating expenses 35,532us-gaap_OperatingExpenses 13,780us-gaap_OperatingExpenses 13,791us-gaap_OperatingExpenses
Loss from operations (35,532)us-gaap_OperatingIncomeLoss (13,780)us-gaap_OperatingIncomeLoss (13,791)us-gaap_OperatingIncomeLoss
Other income (expense):      
Interest income 28us-gaap_InvestmentIncomeNet    
Interest expense (870)us-gaap_InterestExpense   (97)us-gaap_InterestExpense
Foreign currency transaction gains (losses), net (104)us-gaap_ForeignCurrencyTransactionGainLossBeforeTax (247)us-gaap_ForeignCurrencyTransactionGainLossBeforeTax 8us-gaap_ForeignCurrencyTransactionGainLossBeforeTax
Total other income (expense), net (946)us-gaap_NonoperatingIncomeExpense (247)us-gaap_NonoperatingIncomeExpense (89)us-gaap_NonoperatingIncomeExpense
Net loss (36,478)us-gaap_NetIncomeLoss (14,027)us-gaap_NetIncomeLoss (13,880)us-gaap_NetIncomeLoss
Accretion of redeemable convertible preferred stock to redemption value (92)us-gaap_TemporaryEquityAccretionToRedemptionValueAdjustment (213)us-gaap_TemporaryEquityAccretionToRedemptionValueAdjustment (67)us-gaap_TemporaryEquityAccretionToRedemptionValueAdjustment
Net loss attributable to common stockholders (36,570)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic (14,240)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic (13,947)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Net loss per share attributable to common stockholders, basic and diluted $ (3.00)us-gaap_EarningsPerShareBasicAndDiluted $ (19.53)us-gaap_EarningsPerShareBasicAndDiluted $ (19.65)us-gaap_EarningsPerShareBasicAndDiluted
Weighted average common shares outstanding, basic and diluted 12,189,155us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 729,001us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 709,678us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted
Comprehensive loss:      
Net loss (36,478)us-gaap_NetIncomeLoss (14,027)us-gaap_NetIncomeLoss (13,880)us-gaap_NetIncomeLoss
Other comprehensive loss:      
Unrealized loss on marketable securities (35)us-gaap_MarketableSecuritiesUnrealizedGainLoss    
Total other comprehensive loss (35)us-gaap_OtherComprehensiveIncomeLossNetOfTax    
Total comprehensive loss $ (36,513)us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest $ (14,027)us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest $ (13,880)us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest