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Commitments and Contingencies - Additional Information (Detail)
$ in Millions
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Mar. 09, 2023
Aug. 09, 2021
Oct. 27, 2020
USD ($)
Aug. 04, 2020
May 28, 2020
USD ($)
ft²
Dec. 11, 2019
USD ($)
Aug. 08, 2019
Nov. 05, 2018
Jan. 31, 2023
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
Dec. 31, 2022
USD ($)
Nov. 30, 2016
USD ($)
Other Commitments [Line Items]                              
Weighted average remaining lease term in years                   6 years 3 months 18 days   6 years 3 months 18 days   6 years 9 months 18 days  
Weighted average discount rate                   11.00%   11.00%   11.00%  
Lease expenses                   $ 0.1 $ 0.1 $ 0.2 $ 0.2    
Pennsylvania [Member] | Office [Member]                              
Other Commitments [Line Items]                              
Operating lease term             3 years 6 months                
Lease extension period 3 years           3 years                
Lease term commencement date Sep. 01, 2023           Feb. 15, 2020                
Pennsylvania [Member] | Office and Lab [Member]                              
Other Commitments [Line Items]                              
Lease extension period               2 years              
Lease term commencement date               Jan. 01, 2019              
Lease term expiration date   Dec. 31, 2022   Dec. 31, 2021       Dec. 31, 2020 Dec. 31, 2023            
Massachusetts [Member] | Office [Member]                              
Other Commitments [Line Items]                              
Area of office space | ft²         17,705                    
Lease term expiration date         Oct. 30, 2029                    
Massachusetts [Member] | Office [Member] | Letter of Credit                              
Other Commitments [Line Items]                              
Letter of credit         $ 1.3                    
Massachusetts [Member] | Office Sublease [Member]                              
Other Commitments [Line Items]                              
Lease term commencement date     Dec. 04, 2020                        
Lease term expiration date     Oct. 30, 2029                        
Massachusetts [Member] | Office Sublease [Member] | First Sublease Year [Member]                              
Other Commitments [Line Items]                              
Annual base rent     $ 0.8                        
Massachusetts [Member] | Office Sublease [Member] | First Sublease Year [Member] | Letter of Credit                              
Other Commitments [Line Items]                              
Lease security deposits letters of credit     0.8                        
Massachusetts [Member] | Office Sublease [Member] | Final Sublease Year [Member]                              
Other Commitments [Line Items]                              
Annual base rent     1.0                        
Massachusetts [Member] | Office Sublease [Member] | Sixth Sublease Year | Letter of Credit                              
Other Commitments [Line Items]                              
Lease security deposits letters of credit     $ 0.4                        
WFUHS [Member]                              
Other Commitments [Line Items]                              
License agreement consideration deduction percentage                             60.00%
WFUHS [Member] | Maximum [Member]                              
Other Commitments [Line Items]                              
Milestone payments                             $ 2.6
IU [Member]                              
Other Commitments [Line Items]                              
License agreement consideration deduction percentage                             20.00%
IU [Member] | Maximum [Member]                              
Other Commitments [Line Items]                              
Milestone payments                             $ 2.6
Annual royalty pay obligation                             $ 0.1
WFUHS and IU [Member] | Research and Development Expenses [Member]                              
Other Commitments [Line Items]                              
Milestone expenses                           $ 0.3  
WFUHS and IU [Member] | Maximum [Member]                              
Other Commitments [Line Items]                              
Payment for license agreements           $ 0.1