Consolidated Statements of Changes in Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]
Balances at Dec. 31, 2019	$ (694)	$ 6	$ 22,432	$ (23,132)
Beginning balance, shares at Dec. 31, 2019		6,091,250
Capital contributions from related party	17,995		17,995
Merger with Zafgen Inc.	37,119	$ 3	37,116
Merger with Zafgen Inc., Shares		3,124,337
Private Placement, net of transaction costs	74,850	$ 6	74,844
Shares issued to private placement, Shares		6,105,359
Issuance of Common Stock to placement agent for advisory fees in lieu of cash and other issuances of common stock	742		742
Issuance of common stock to placement agent for advisory fees in lieu of cash and other issuances of common stock, Shares		46,784
Stock-based compensation expense	2,161		2,161
Unrealized gain (loss) on marketable debt securities	1				$ 1
Net loss	(42,482)			(42,482)
Balances at Dec. 31, 2020	89,692	$ 15	155,290	(65,614)	1
Ending balance, shares at Dec. 31, 2020		15,367,730
Issuance of Common Stock. Net	19,885	$ 3	19,882
Issuance of Common Stock. Net, shares		2,342,720
Stock-based compensation expense	5,473		5,473
Unrealized gain (loss) on marketable debt securities	(1)				$ (1)
Net loss	(50,636)			(50,636)
Balances at Dec. 31, 2021	$ 64,413	$ 18	$ 180,645	$ (116,250)
Ending balance, shares at Dec. 31, 2021		17,710,450