Description of Business and Organization - Additional Information (Detail)				1 Months Ended		12 Months Ended
	Aug. 14, 2020 USD ($)	Jun. 30, 2020 USD ($)	May 28, 2020 $ / shares shares	Mar. 23, 2022 USD ($)	Jul. 31, 2021 USD ($) shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares
Common stock, par value per share | $ / shares						$ 0.001	$ 0.001
Common stock, shares issued | shares						17,710,450	15,367,730
Net loss						$ 50,636,000	$ 42,482,000
Accumulated deficit						(116,250,000)	(65,614,000)
Cash and cash equivalents						$ 70,097,000	$ 68,148,000
Private Offering [Member]
Proceeds from issuance common stock and warrants net offering costs		$ 75,400,000
Common Stock [Member]
Issuance of common stock | shares						2,342,720
Common Stock [Member] | ATM Offering Program [Member]
Common stock, shares issued | shares						2,354,244
Issuance of common stock | shares					2,342,720
Gross proceeds from issuance of common stock					$ 20,500,000
Common Stock [Member] | Subsequent Event [Member] | ATM Offering Program [Member]
Gross sales proceeds under sales agreement remaining amount				$ 29,200,000
Maximum [Member] | Common Stock [Member] | ATM Offering Program [Member]
Aggregate sale of shares of our common stock	$ 50,000,000
Zafgen [Member]
Reverse stock split of common stock			1-for-12
Common stock, par value per share | $ / shares			$ 0.001
Cash, cash equivalents, restricted cash and marketable debt securities acquired merger		$ 42,900,000
Zafgen [Member] | Merger Agreement [Member]
Exchange rate of shares issued per share			60,912.5005
Common stock, shares issued | shares			6,091,250
Chondrial [Member] | Merger Agreement [Member]
Common stock, par value per share | $ / shares			$ 0.001