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Accrued Expenses (Tables)
9 Months Ended
Sep. 30, 2018
Accrued Liabilities [Abstract]  
Schedule of Accrued Liabilities [Table Text Block]
Accrued expenses consist of the following: 
 
 
 
September 30,
2018
(unaudited)
 
 
December 31,
2017
 
Payroll and Benefits
 
$
650,797
 
 
$
788,551
 
Clinical Trials
 
 
302,292
 
 
 
807,322
 
Professional Fees
 
 
169,572
 
 
 
149,273
 
Consulting
 
 
18,646
 
 
 
57,487
 
Short-Term Portion of Capital Financing Obligation
 
 
6,445
 
 
 
11,214
 
Total Accrued Expenses
 
$
1,147,752
 
 
$
1,813,847