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Income Taxes - Schedule of Reconciliation of the Federal Statutory Income Tax Rate to the Effective Tax Rate (Details)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Income Tax Disclosure [Abstract]      
Federal statutory rate 35.00% 35.00% 35.00%
Effect of:      
State taxes, net of federal tax benefit 0.00% 0.60% 2.50%
Change in valuation allowance (21.00%) (11.20%) 13.40%
Research and development tax credit 1.10% 1.20% 0.80%
Convertible preferred stock warrants 0.00% 0.00% (1.30%)
Stock-based compensation (1.10%) (1.90%) 2.90%
Foreign differential (14.10%) (15.60%) (17.10%)
Non-deductible/non-taxable items (0.60%) (0.20%) 0.00%
Other, net (0.10%) (0.30%) (3.20%)
Total (0.80%) 7.60% 33.00%