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Balance Sheet Accounts and Supplemental Disclosures - Accrued Expenses (Details) - USD ($)
$ in Thousands
Dec. 31, 2021
Dec. 31, 2020
Balance Sheet Related Disclosures [Abstract]    
Accrued compensation and related expenses $ 4,177 $ 3,688
Accrued professional fees 569 408
Accrued research and development expenses 7,953 10,936
Other 154 230
Total accrued expenses $ 12,853 $ 15,262