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Balance Sheet Accounts and Supplemental Disclosures - Accrued Expenses (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Balance Sheet Related Disclosures [Abstract]    
Accrued compensation and related expenses $ 2,421 $ 1,588
Accrued research and contract manufacturing expenses 5,577 2,961
Other 763 326
Total accrued expenses $ 8,761 $ 4,875