CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $) In Thousands, except Share data	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive Loss [Member]	Retained Deficit [Member]
Balance at Dec. 31, 2009	$ 595,792	$ 29	$ 700,814	$ (1,718)	$ (103,333)
Balance, shares at Dec. 31, 2009		291,134,000
Net issuance of restricted stock awards and recognition of stock-based compensation	1,270	1	1,269
Net issuance of restricted stock awards and recognition of stock-based compensation, shares		4,183,000
Contribution of services	168		168
Warrants issued associated with Contingent Equity Agreement	11,940		11,940
Common stock issued in connection with conversions of 8.00% Notes	3,415		3,415
Common stock issued in connection with conversions of 8.00% Notes, shares		3,246,000
Warrants exercised associated with the 8.00% Notes	15,234	1	15,233
Warrants exercised associated with the 8.00% Notes, shares		8,110,000
Conversion of Thermo debt to equity	2,426		2,426
Conversion of Thermo debt to equity, shares		2,526,000
Issuance of stock in connection with contingent consideration	1,190		1,190
Issuance of stock in connection with contingent consideration, shares		760,000
Other comprehensive income (loss)	1,450			1,450
Net loss	(97,467)				(97,467)
Balance at Dec. 31, 2010	535,418	31	736,455	(268)	(200,800)
Balance, shares at Dec. 31, 2010		309,959,000
Net issuance of restricted stock awards and recognition of stock-based compensation	2,017		2,017
Net issuance of restricted stock awards and recognition of stock-based compensation, shares		994,000
Contribution of services	319		319
Warrants issued associated with Contingent Equity Agreement	5,955		5,955
Common stock issued in connection with conversions of 8.00% Notes	942		942
Common stock issued in connection with conversions of 8.00% Notes, shares		773,000
Warrants exercised associated with the 8.00% Notes	1,064		1,064
Warrants exercised associated with the 8.00% Notes, shares		575,000
Issuance of stock in connection with interest payments for 8.00% Notes	572		572
Issuance of stock in connection with interest payments for 8.00% Notes, shares		1,300,000
Issuance of stock in connection with contingent consideration	1,827		1,827
Issuance of stock in connection with contingent consideration, shares		1,857,000
Issuance of warrants and beneficial conversion feature associated with 5.0% Notes	24,868		24,868
Issuance of stock for legal settlements and other transactions	644		644
Issuance of stock for legal settlements and other transactions, shares		566,000
Issuance of nonvoting stock to Thermo for contingent equity draws	17,750	4	17,746
Issuance of nonvoting stock to Thermo for contingent equity draws, shares		36,606,000
Issuance of stock through employee stock purchase plan	175		175
Issuance of stock through employee stock purchase plan, shares		428,000
Other comprehensive income (loss)	(2,832)			(2,832)
Net loss	(54,924)				(54,924)
Balance at Dec. 31, 2011	533,795	35	792,584	(3,100)	(255,724)
Balance, shares at Dec. 31, 2011		353,058,000
Net issuance of restricted stock awards and recognition of stock-based compensation	706		706
Net issuance of restricted stock awards and recognition of stock-based compensation, shares		711,000
Contribution of services	529		529
Warrants issued associated with Contingent Equity Agreement	8,079		8,079
Common stock issued in connection with conversions of 8.00% Notes	1,338		1,338
Common stock issued in connection with conversions of 8.00% Notes, shares		1,903,000
Warrants exercised associated with the 8.00% Notes	420		420
Warrants exercised associated with the 8.00% Notes, shares		191,000
Issuance of stock in connection with interest payments for 8.00% Notes	912	1	911
Issuance of stock in connection with interest payments for 8.00% Notes, shares		2,737,000
Issuance of stock in connection with contingent consideration	2,209	1	2,208
Issuance of stock in connection with contingent consideration, shares		5,232,000
Issuance of stock for legal and consulting services	24		24
Issuance of nonvoting stock to Thermo for contingent equity draws	57,250	12	57,238
Issuance of nonvoting stock to Thermo for contingent equity draws, shares		124,310,000
Issuance of stock through employee stock purchase plan	138		138
Issuance of stock through employee stock purchase plan, shares		944,000
Other comprehensive income (loss)	1,342			1,342
Net loss	(112,198)				(112,198)
Balance at Dec. 31, 2012	$ 494,544	$ 49	$ 864,175	$ (1,758)	$ (367,922)
Balance, shares at Dec. 31, 2012		489,086,000