Cash and Cash Equivalents, and Investments and Fair Value Measurements - Schedule of Available For Sale Securities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	$ 1,622,394
Fair Value	1,603,221
Cash and cash equivalents:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	402,122	$ 854,078
Unrealized Gain	0	0
Unrealized Loss	(33)	0
Fair Value	402,089	854,078
Short-term investments:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	992,806	692,320
Unrealized Gain	10	40
Unrealized Loss	(11,528)	(579)
Fair Value	981,288	691,781
Long-term investments:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	273,351	749,377
Unrealized Gain	8	0
Unrealized Loss	(7,630)	(3,384)
Fair Value	265,729	745,993
Commercial paper \| Short-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	81,649	124,211
Unrealized Gain	0	2
Unrealized Loss	(382)	(33)
Fair Value	81,267	124,180
Corporate debt securities \| Short-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	831,482	552,609
Unrealized Gain	10	36
Unrealized Loss	(9,889)	(546)
Fair Value	821,603	552,099
Corporate debt securities \| Long-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	198,816	724,517
Unrealized Gain	8	0
Unrealized Loss	(5,582)	(3,277)
Fair Value	193,242	721,240
U.S. treasury securities \| Short-term investments: \| Level 1
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	79,675
Unrealized Gain	0
Unrealized Loss	(1,257)
Fair Value	78,418
U.S. treasury securities \| Long-term investments: \| Level 1
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	74,535	24,860
Unrealized Gain	0	0
Unrealized Loss	(2,048)	(107)
Fair Value	72,487	24,753
Agency bonds \| Short-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost		15,500
Unrealized Gain		2
Unrealized Loss		0
Fair Value		15,502
Cash \| Cash and cash equivalents:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	45,885	30,324
Unrealized Gain	0	0
Unrealized Loss	0	0
Fair Value	45,885	30,324
Money market funds \| Cash and cash equivalents: \| Level 1
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	199,003	823,754
Unrealized Gain	0	0
Unrealized Loss	0	0
Fair Value	199,003	$ 823,754
Commercial paper \| Cash and cash equivalents: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	157,234
Unrealized Gain	0
Unrealized Loss	(33)
Fair Value	$ 157,201

Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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Amount, before tax, of unrealized loss in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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