Exhibit 21.1

List of Subsidiaries

Subsidiary	State of Incorporation	D/B/A
SXC Health Solutions, Inc. (formerly named Systems Xcellence USA, Inc.)	Texas	SXC
SXC Acquisition Corp.	Delaware	Zynchros
Health Business Systems, Inc.	Pennsylvania	HBS HBS, Inc. HBS, an SXC Company
informedRx, Inc. (formerly National Medical Health Card Systems, Inc.)
SXC Comet LLC	Delaware
SXC Health Solutions TPA, LLC	Delaware
National Medical Health Card IPA, Inc.	New York	NMHCRX IPA
NMHC Group Solutions Insurance, Inc.	Delaware
NMHCRX Mail Order, Inc.	Delaware	informedMAIL
PCN DE Corp.	Delaware
Pharmaceutical Care Network	California	PCN
Portland Professional Pharmacy	Maine	Ascend Compounding
Portland Professional Pharmacy Associates	Maine	Ascend SpecialtyRx
Hawaii IRX, LLC	Hawaii	Hawaii Ascend Pharmacy
Massachusetts IRX LLC	Massachusetts	Massachusetts Ascend Pharmacy
MedfusionRx, LLC	Alabama
Medtown of North Georgia, LLC	Alabama
Bayou State Pharmacy, LLC	Louisiana
AssuranceRx, LLC	Alabama
Nevada IRX, LLC	Nevada	Ascend SpecialtyRx
Medmetrics Acquisition Corp.	Delaware	Medmetrics Health Partners
PTRx Inc.	Delaware
IRX Financing I LLC	Delaware
SaveDirectRx, Inc.	Texas
HealthTran LLC	Delaware
HT Three, LLC	Colorado	HealthTrans Pharmacy/J&L Pharmacy
HT Access, LLC	Colorado