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Note 10 - Income Taxes (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
    Year Ended December 31,
    2019   2018
Domestic   $
(14,965
)   $
(17,855
)
Foreign    
(27
)    
(2,874
)
Total   $
(14,992
)   $
(20,729
)
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
    Year Ended December 31,
    2019   2018
Income tax benefit computed at federal statutory tax rate   $
(3,148
)   $
(4,348
)
Permanent differences    
1
     
6
 
Write-off of deferred tax asset    
2,048
     
-
 
Stock compensation - permanent items    
-
     
325
 
State income taxes, net of federal benefit    
(930
)    
(958
)
Tax credits    
(465
)    
(1,466
)
Change in valuation allowance    
2,449
     
5,409
 
Foreign rate differential    
5
     
602
 
Other    
40
     
430
 
Total   $
-
    $
-
 
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
    Year Ended December 31,
    2019   2018
Deferred tax assets:                
Net operating loss carryforwards   $
11,090
    $
6,742
 
Federal and state tax credits    
3,587
     
3,122
 
Accrued expenses    
-
     
411
 
Patents    
74
     
132
 
Stock-based compensation    
-
     
1,782
 
Other    
59
     
169
 
Total deferred tax assets    
14,810
     
12,358
 
Valuation allowance    
(14,810
)    
(12,358
)
Net deferred assets   $
-
    $
-