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Note 4 - Property and Equipment, Net - Summary of Property and Equipment (Details) - USD ($)
Sep. 30, 2019
Dec. 31, 2018
Property and equipment $ 1,090,000
Accumulated depreciation (827,000)
Property and equipment, net 0 263,000
Computer Equipment and Software [Member]    
Property and equipment 211,000
Furniture and Fixtures [Member]    
Property and equipment 365,000
Laboratory Equipment [Member]    
Property and equipment $ 514,000