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Note 10 - Restructuring Charges
6 Months Ended
Jun. 30, 2019
Notes to Financial Statements  
Restructuring and Related Activities Disclosure [Text Block]
10.
  Restructuring Charges
 
In
April 2019,
the Board of Directors approved a plan (
“2019
Restructuring Program”) to reduce operating expenses as the Company evaluates its strategic alternatives following the release of top-line data from the PATENCY-
2
clinical trial of vonapanitase on
March 28, 2019.
The restructuring initiatives are company-wide. The remainder of the charges are expected to be incurred by the end of the fiscal year ending
December 31, 2019 (
“Fiscal Year
2019”
). These actions are expected to result in pre-tax charges of 
$2.9
million, all of which are anticipated to be cash expenditures.
 
Changes in the restructuring accrual during the
first
 
six
months ended
June 30, 2019 
are summarized below (in thousands): 
 
 
    As of December 31,
2018
  Charges/(Benefits)   Payment/Other   As of June 30,
2019
2019 Restructuring Program                                
Employee Severance   $
-
    $
2,900
    $
(1,391
)   $
1,509
 
Total   $
-
    $
2,900
    $
(1,391
)   $
1,509