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Note 1 - Organization and Operations (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Proportions of Patients Experiencing Adverse Events [Table Text Block]
    Vonapanitase
N=399
  Placebo
N=204
Vascular Stenosis    
35.1
%    
41.7
%
Fistula Thrombosis    
16.8
%    
18.6
%
Local swelling    
5.0
%    
2.0
%
Hematoma    
5.0
%    
3.9
%