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Note 12 - Quarterly Financial Information (Unaudited, in Thousands, Except Share and Per Share Data) (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Quarterly Financial Information [Table Text Block]
    Three Months Ended (a)
    March 31,   June 30,   September 30,   December 31,
    2018   2018   2018   2018
Operating expenses   $
6,365
    $
5,000
    $
4,622
    $
5,385
 
Net loss attributable to common stockholders    
(6,081
)    
(4,879
)    
(4,510
)    
(5,259
)
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $
(0.34
)   $
(0.28
)   $
(0.25
)   $
(0.27
)
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted    
17,674,729
     
17,674,729
     
17,824,186
     
19,221,292
 
    Three Months Ended (a)
    March 31,   June 30,   September 30,   December 31,
    2017   2017   2017   2017
Operating expenses   $
6,480
    $
5,986
    $
12,306
 
  $
5,590
 
Net loss attributable to common stockholders    
(6,498
)    
(5,608
)    
(19,054
)
   
(5,551
)
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $
(0.39
)   $
(0.33
)   $
(1.08
)
  $
(0.33
)
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted    
16,636,201
     
17,207,672
     
17,619,418
(b)
   
17,619,418