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Note 6 - Stock-based Compensation (Tables)

9 Months Ended

Sep. 30, 2018

Share-based Compensation, Stock Options, Activity [Table Text Block]

	Options			Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (years)		Aggregate Intrinsic Value

Outstanding at December 31, 2017		2,681,072		$	7.18		6.8	$	121
Granted		2,041,600		$	2.61
Exercised		-
Forfeited		(83,433	)	$	5.82
Expired		(42,013	)	$	13.30
Outstanding at September 30, 2018		4,597,226		$	5.12		7.7	$	130
Exercisable at September 30, 2018		1,946,255		$	7.49		5.9	$	125
Vested or expected to vest at September 30, 2018 (1)		4,597,226		$	5.12		7.7	$	130

Common Stock Reserved for Future Issuance [Table Text Block]

<div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt"><div style="display: inline; color: Black"> </div></td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; color: Black">September 30,</div></td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt"><div style="display: inline; color: Black"> </div></td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; color: Black">December 31,</div></td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt"><div style="display: inline; color: Black"> </div></td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; color: Black">2018</div></td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt"><div style="display: inline; color: Black"> </div></td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; color: Black">2017</div></td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td colspan="3" style="font-size: 10pt; text-align: center"><div style="display: inline; color: Black"> </div></td> <td><div style="display: inline; color: Black"> </div></td> <td colspan="3"><div style="display: inline; color: Black"> </div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; font-size: 10pt; text-align: left"><div style="display: inline; color: Black">Conversion of Series A Preferred Stock</div></td> <td style="width: 1%; font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="width: 1%; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="width: 12%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">22,112,775</div></div></td> <td style="width: 1%; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="width: 1%; font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="width: 1%; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="width: 12%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">22,112,775</div></div></td> <td style="width: 1%; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left"><div style="display: inline; color: Black">Stock-based compensation awards</div></td> <td style="font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">5,038,511</div></div></td> <td style="font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">3,572,457</div></div></td> <td style="font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt"><div style="display: inline; color: Black">Employee Stock Purchase Plan</div></td> <td style="font-size: 10pt; padding-bottom: 1pt"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">140,479</div></div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; padding-bottom: 1pt"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">192,463</div></div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; padding-bottom: 2.25pt"><div style="display: inline; color: Black">Total</div></td> <td style="font-size: 10pt; padding-bottom: 2.25pt"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">27,291,765</div></div></td> <td style="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="font-size: 10pt; padding-bottom: 2.25pt"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> <td style="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; color: Black">25,877,695</div></div></td> <td style="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: left"><div style="display: inline; color: Black"> </div></td> </tr> </table></div>