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Note 8 - Net Loss Per Share Attributable to Common Stockholders (Tables)
6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
    Three Months Ended June 30,   Six Months Ended June 30,
    2018   2017   2018   2017
Outstanding stock options    
4,447,226
     
2,783,570
     
4,447,226
     
2,783,570
 
Convertible preferred stock    
22,112,775
     
-
     
22,112,775
     
-
 
     
26,560,001
     
2,783,570
     
26,560,001
     
2,783,570