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Note 1 - Organization and Operations (Details Textual) - USD ($)
$ in Thousands
3 Months Ended
Nov. 12, 2015
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Cash, Cash Equivalents, and Short-term Investments   $ 34,100    
Retained Earnings (Accumulated Deficit)   (166,275)   $ (159,777)
Proceeds from Issuance of Common Stock   $ 105  
Sales Agreement [Member] | Cowen and Company, LLC [Member]        
Sale of Stock, Maximum Value of Stock Offered $ 40,000      
Sales of Stock, Commission Paid   3.00%    
Stock Issued During Period, Shares, New Issues   93,512    
Proceeds from Issuance of Common Stock   $ 200    
Payments of Stock Issuance Costs   $ 100