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Note 12 - Quarterly Financial Information (Unaudited, in Thousands, Except Share and Per Share Data) (Tables)
 12 Months Ended
Dec. 31, 2016
Notes Tables  
Quarterly Financial Information [Table Text Block]
    Three Months Ended
    March 31,   June 30,   September 30,   December 31,
    2016   2016   2016   2016
Operating expenses   $
6,819
     $
7,854
     $
7,166
     $
6,866
  
Net loss attributable to common stockholders    
(6,552
 )    
(7,905
 )    
(7,107
 )    
(6,962
 )
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $
(0.40
 )   $
(0.48
 )   $
(0.43
 )   $
(0.42
 )
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted    
16,507,586
      
16,561,239
      
16,582,276
      
16,595,502
  
    Three Months Ended
    March 31,   June 30,   September 30,   December 31,
    2015   2015   2015   2015
Operating expenses   $
4,620
     $
4,981
     $
5,082
     $
6,187
  
Net loss attributable to common stockholders    
(4,580
 )    
(5,072
 )    
(5,383
 )    
(6,342
 )
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $
(0.28
 )   $
(0.31
 )   $
(0.33
 )   $
(0.38
 )
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted    
16,448,688
      
16,449,937
      
16,466,945
      
16,490,430