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Note 8 - Net Loss Per Share Attributable to Common Stockholders (Tables)
3 Months Ended
Mar. 31, 2016
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
    Three Months Ended March 31,
    2016   2015
Outstanding stock options     2,203,975       1,635,219  
Outstanding ESPP shares     8,841       2,859  
      2,212,816       1,638,078